Office staff responsibilities include performing clerical and administrative duties for an office. Clerical duties support the day-to-day operations of an office, including answering phones, sorting mail, scheduling meetings, and business trips, welcoming visitors, and filing documents.Summary. Performs a range of basic office support activities for a unit/department, such as answering phones and directing calls, greeting and directing visitors, answering questions and performing routine clerical, data entry, and/or word processing work as assigned. They handle responsibilities such as answering phone calls, managing schedules, and organizing files. Often the first point of contact for clients or visitors, they play a prominent role in creating a welcoming environment. Office assistants may also assist with data entry, document preparation, and correspondence.